June 2023

We’ve combined simulation and experiment to reveal how disease mutations disrupt the normal auto-inhibition of protein phosphatase 2A (PP2A) by redistributing its allosteric pathways. This is a joint work with Yongna Xing’s group and has been published in JCP‘s special issue on “New Views of Allostery“! Congratulations to our group members, Kirill, Yunrui, and Michael O’Connor, who contributed to this work!